Significant strides have been made in delineating the white matter architecture in the living human brain in the last two decades. These pathways have been identified as pivotal in supporting cognitive functions, with their variability closely associated with differences in cognitive performance, psychiatric conditions, and neurological manifestations. This underscores the hypothesis that brain function is not confined to regions but emerges from interactions facilitated by white-matter connections. In our presentation, we will unveil cutting-edge methodologies developed recently in our lab - namely, the disconnectome, functionnectome and emuse - to explore these emergent properties. We will discuss their implications for understanding complex neuroscientific phenomena, such as consciousness and post-stroke neuropsychological recovery.

Papers discussed will be the following

• Foulon, C., et al. (2018). "Advanced lesion symptom mapping analyses and implementation as BCBtoolkit." Gigascience 7(3): 1-17.
• Talozzi, L., et al. (2023). "Latent disconnectome prediction of long-term cognitive-behavioural symptoms in stroke." Brain 146(5): 1963-1978.
• Pacella, V., et al. (2019). "Anosognosia for hemiplegia as a tripartite disconnection syndrome." Elife 8.
• Thiebaut de Schotten, M. and S. J. Forkel (2022). "The emergent properties of the connected brain." Science 378(6619): 505-510.
• Thiebaut de Schotten, M., et al. (2020). "Brain disconnections link structural connectivity with function and behaviour." Nat Commun 11(1): 5094.