To link neural, affective, and motivational levels of analysis, we have proposed a "deep science" approach. Recent neuroimaging research has linked neural activity to anticipatory affective experience (i.e., in the Nucleus Accumbens or NAcc to positive arousal and in the Anterior Insula or AIns to general or negative arousal). Activity in circuits implicated in anticipatory affect further predicts motivated behavior across diverse scenarios (with NAcc activity predicting approach and AIns activity predicting avoidance). Extended links can now be forged from lower levels of analysis related to neurochemistry (e.g., release of dopamine and norepinephrine in target regions), as well as to higher levels of analysis related to aggregate choice (e.g., increases versus decreases in market demand). Innovation of new methods with matching resolution should continue to support linking previously disparate levels of analysis, which may more rapidly generate applications that can improve health and welfare.

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